April 22, 1861
- The Clarksburg (present-day West Virginia) Convention calls for an anti-secessionist convention to be held in May 1861
- Maryland Governor Thomas Holliday Hicks calls a session of the Maryland legislature to consider secession
- Robert E. Lee accepts command of Virginia forces
A Chronological History of the Civil War in America1
- U. S. Arsenal at Napoleon, Ark., seized by the rebels.
- New York city appropriated $1,000,000 to equip volunteers, and $500,000 for their families.
- A Chronological History of the Civil War in America by Richard Swainson Fisher, New York, Johnson and Ward, 1863